c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis.
Identifieur interne : 000177 ( Main/Exploration ); précédent : 000176; suivant : 000178c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis.
Auteurs : Christian Neumann [Allemagne] ; Jonas Blume [Australie] ; Urmi Roy [Allemagne] ; Peggy P. Teh [Australie] ; Ajithkumar Vasanthakumar [Australie] ; Alexander Beller [Allemagne] ; Yang Liao [Australie] ; Frederik Heinrich [Allemagne] ; Teresita L. Arenzana [États-Unis] ; Jason A. Hackney [États-Unis] ; Celine Eidenschenk [États-Unis] ; Eric J C. Gálvez [Allemagne] ; Christina Stehle [Allemagne] ; Gitta A. Heinz [Allemagne] ; Patrick Maschmeyer [Allemagne] ; Tom Sidwell [Australie] ; Yifang Hu [Australie] ; Derk Amsen [Pays-Bas] ; Chiara Romagnani [Allemagne] ; Hyun-Dong Chang [Allemagne] ; Andrey Kruglov [Allemagne, Russie] ; Mir-Farzin Mashreghi [Allemagne] ; Wei Shi [Australie] ; Till Strowig [Allemagne] ; Sascha Rutz [États-Unis] ; Axel Kallies [Australie] ; Alexander Scheffold [Allemagne]Source :
- Nature immunology [ 1529-2916 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cellules Th17 (immunologie), Cellules cultivées (MeSH), Colite (immunologie), Cytokines (métabolisme), Dysbiose (MeSH), Homéostasie (MeSH), Immunoglobuline A (biosynthèse), Interleukine-10 (biosynthèse), Intestins (immunologie), Lymphocytes T régulateurs (enzymologie), Lymphocytes T régulateurs (immunologie), Microbiote (MeSH), Protéines proto-oncogènes c-maf (génétique), Protéines proto-oncogènes c-maf (métabolisme), Protéines proto-oncogènes c-maf (physiologie), Régulation de l'expression des gènes (MeSH), Souris de lignée C57BL (MeSH).
- MESH :
- biosynthèse : Immunoglobuline A, Interleukine-10.
- enzymologie : Lymphocytes T régulateurs.
- génétique : Protéines proto-oncogènes c-maf.
- immunologie : Cellules Th17, Colite, Intestins, Lymphocytes T régulateurs.
- métabolisme : Cytokines, Protéines proto-oncogènes c-maf.
- physiologie : Protéines proto-oncogènes c-maf.
- Animaux, Cellules cultivées, Dysbiose, Homéostasie, Microbiote, Régulation de l'expression des gènes, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals (MeSH), Cells, Cultured (MeSH), Colitis (immunology), Cytokines (metabolism), Dysbiosis (MeSH), Gene Expression Regulation (MeSH), Homeostasis (MeSH), Immunoglobulin A (biosynthesis), Interleukin-10 (biosynthesis), Intestines (immunology), Mice, Inbred C57BL (MeSH), Microbiota (MeSH), Proto-Oncogene Proteins c-maf (genetics), Proto-Oncogene Proteins c-maf (metabolism), Proto-Oncogene Proteins c-maf (physiology), T-Lymphocytes, Regulatory (enzymology), T-Lymphocytes, Regulatory (immunology), Th17 Cells (immunology).
- MESH :
- chemical , biosynthesis : Immunoglobulin A, Interleukin-10.
- chemical , genetics : Proto-Oncogene Proteins c-maf.
- chemical , metabolism : Cytokines, Proto-Oncogene Proteins c-maf.
- enzymology : T-Lymphocytes, Regulatory.
- immunology : Colitis, Intestines, T-Lymphocytes, Regulatory, Th17 Cells.
- chemical , physiology : Proto-Oncogene Proteins c-maf.
- Animals, Cells, Cultured, Dysbiosis, Gene Expression Regulation, Homeostasis, Mice, Inbred C57BL, Microbiota.
Abstract
Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinal Treg cells to constrain microbiota-dependent interleukin (IL)-17-producing helper T cell (TH17 cell) and immunoglobulin A responses critically required expression of the transcription factor c-Maf. The terminal differentiation and function of several intestinal Treg cell populations, including RORγt+ Treg cells and follicular regulatory T cells, were c-Maf dependent. c-Maf controlled Treg cell-derived IL-10 production and prevented excessive signaling via the kinases PI(3)K (phosphatidylinositol-3-OH kinase) and Akt and the metabolic checkpoint kinase complex mTORC1 (mammalian target of rapamycin) and expression of inflammatory cytokines in intestinal Treg cells. c-Maf deficiency in Treg cells led to profound dysbiosis of the intestinal microbiota, which when transferred to germ-free mice was sufficient to induce exacerbated intestinal TH17 responses, even in a c-Maf-competent environment. Thus, c-Maf acts to preserve the identity and function of intestinal Treg cells, which is essential for the establishment of host-microbe symbiosis.
DOI: 10.1038/s41590-019-0316-2
PubMed: 30778241
Affiliations:
- Allemagne, Australie, Pays-Bas, Russie, États-Unis
- Berlin, Californie, District fédéral central, Hollande-Septentrionale, Schleswig-Holstein, Victoria (État)
- Amsterdam, Berlin, Kiel, Melbourne, Moscou
- Université d'Amsterdam, Université de Melbourne
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Beller, Alexander" sort="Beller, Alexander" uniqKey="Beller A" first="Alexander" last="Beller">Alexander Beller</name>
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<author><name sortKey="Liao, Yang" sort="Liao, Yang" uniqKey="Liao Y" first="Yang" last="Liao">Yang Liao</name>
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<author><name sortKey="Hackney, Jason A" sort="Hackney, Jason A" uniqKey="Hackney J" first="Jason A" last="Hackney">Jason A. Hackney</name>
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<author><name sortKey="Eidenschenk, Celine" sort="Eidenschenk, Celine" uniqKey="Eidenschenk C" first="Celine" last="Eidenschenk">Celine Eidenschenk</name>
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<author><name sortKey="Galvez, Eric J C" sort="Galvez, Eric J C" uniqKey="Galvez E" first="Eric J C" last="Gálvez">Eric J C. Gálvez</name>
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<author><name sortKey="Stehle, Christina" sort="Stehle, Christina" uniqKey="Stehle C" first="Christina" last="Stehle">Christina Stehle</name>
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</placeName>
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</author>
<author><name sortKey="Sidwell, Tom" sort="Sidwell, Tom" uniqKey="Sidwell T" first="Tom" last="Sidwell">Tom Sidwell</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
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</placeName>
<orgName type="university">Université de Melbourne</orgName>
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<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Hu, Yifang" sort="Hu, Yifang" uniqKey="Hu Y" first="Yifang" last="Hu">Yifang Hu</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Amsen, Derk" sort="Amsen, Derk" uniqKey="Amsen D" first="Derk" last="Amsen">Derk Amsen</name>
<affiliation wicri:level="4"><nlm:affiliation>Sanquin Research, Department of Hematopoiesis and Landsteiner Laboratory, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Sanquin Research, Department of Hematopoiesis and Landsteiner Laboratory, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Romagnani, Chiara" sort="Romagnani, Chiara" uniqKey="Romagnani C" first="Chiara" last="Romagnani">Chiara Romagnani</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Medical Department I, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Department I, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang, Hyun Dong" sort="Chang, Hyun Dong" uniqKey="Chang H" first="Hyun-Dong" last="Chang">Hyun-Dong Chang</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kruglov, Andrey" sort="Kruglov, Andrey" uniqKey="Kruglov A" first="Andrey" last="Kruglov">Andrey Kruglov</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Belozersky Institute of Physico-Chemical Biology and Biological Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Belozersky Institute of Physico-Chemical Biology and Biological Faculty, M.V. Lomonosov Moscow State University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mashreghi, Mir Farzin" sort="Mashreghi, Mir Farzin" uniqKey="Mashreghi M" first="Mir-Farzin" last="Mashreghi">Mir-Farzin Mashreghi</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strowig, Till" sort="Strowig, Till" uniqKey="Strowig T" first="Till" last="Strowig">Till Strowig</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig</wicri:regionArea>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rutz, Sascha" sort="Rutz, Sascha" uniqKey="Rutz S" first="Sascha" last="Rutz">Sascha Rutz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Immunology, Genentech, San Francisco, CA, USA. saschar@gene.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
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<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. axel.kallies@unimelb.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
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</placeName>
</affiliation>
</author>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Immunology, Christian-Albrechts-Universität zu Kiel & Universitätsklinik Schleswig Holstein, Kiel</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">c-Maf-dependent T<sub>reg</sub>
cell control of intestinal T<sub>H</sub>
17 cells and IgA establishes host-microbiota homeostasis.</title>
<author><name sortKey="Neumann, Christian" sort="Neumann, Christian" uniqKey="Neumann C" first="Christian" last="Neumann">Christian Neumann</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blume, Jonas" sort="Blume, Jonas" uniqKey="Blume J" first="Jonas" last="Blume">Jonas Blume</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
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<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roy, Urmi" sort="Roy, Urmi" uniqKey="Roy U" first="Urmi" last="Roy">Urmi Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Teh, Peggy P" sort="Teh, Peggy P" uniqKey="Teh P" first="Peggy P" last="Teh">Peggy P. Teh</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vasanthakumar, Ajithkumar" sort="Vasanthakumar, Ajithkumar" uniqKey="Vasanthakumar A" first="Ajithkumar" last="Vasanthakumar">Ajithkumar Vasanthakumar</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beller, Alexander" sort="Beller, Alexander" uniqKey="Beller A" first="Alexander" last="Beller">Alexander Beller</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liao, Yang" sort="Liao, Yang" uniqKey="Liao Y" first="Yang" last="Liao">Yang Liao</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinrich, Frederik" sort="Heinrich, Frederik" uniqKey="Heinrich F" first="Frederik" last="Heinrich">Frederik Heinrich</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arenzana, Teresita L" sort="Arenzana, Teresita L" uniqKey="Arenzana T" first="Teresita L" last="Arenzana">Teresita L. Arenzana</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Immunology, Genentech, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Immunology, Genentech, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hackney, Jason A" sort="Hackney, Jason A" uniqKey="Hackney J" first="Jason A" last="Hackney">Jason A. Hackney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Bioinformatics and Computational Biology, Genentech, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Bioinformatics and Computational Biology, Genentech, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eidenschenk, Celine" sort="Eidenschenk, Celine" uniqKey="Eidenschenk C" first="Celine" last="Eidenschenk">Celine Eidenschenk</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemical and Cellular Pharmacology, Genentech, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemical and Cellular Pharmacology, Genentech, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galvez, Eric J C" sort="Galvez, Eric J C" uniqKey="Galvez E" first="Eric J C" last="Gálvez">Eric J C. Gálvez</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig</wicri:regionArea>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stehle, Christina" sort="Stehle, Christina" uniqKey="Stehle C" first="Christina" last="Stehle">Christina Stehle</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinz, Gitta A" sort="Heinz, Gitta A" uniqKey="Heinz G" first="Gitta A" last="Heinz">Gitta A. Heinz</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maschmeyer, Patrick" sort="Maschmeyer, Patrick" uniqKey="Maschmeyer P" first="Patrick" last="Maschmeyer">Patrick Maschmeyer</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sidwell, Tom" sort="Sidwell, Tom" uniqKey="Sidwell T" first="Tom" last="Sidwell">Tom Sidwell</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Yifang" sort="Hu, Yifang" uniqKey="Hu Y" first="Yifang" last="Hu">Yifang Hu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amsen, Derk" sort="Amsen, Derk" uniqKey="Amsen D" first="Derk" last="Amsen">Derk Amsen</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Sanquin Research, Department of Hematopoiesis and Landsteiner Laboratory, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Romagnani, Chiara" sort="Romagnani, Chiara" uniqKey="Romagnani C" first="Chiara" last="Romagnani">Chiara Romagnani</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Medical Department I, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Department I, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang, Hyun Dong" sort="Chang, Hyun Dong" uniqKey="Chang H" first="Hyun-Dong" last="Chang">Hyun-Dong Chang</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kruglov, Andrey" sort="Kruglov, Andrey" uniqKey="Kruglov A" first="Andrey" last="Kruglov">Andrey Kruglov</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Belozersky Institute of Physico-Chemical Biology and Biological Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Belozersky Institute of Physico-Chemical Biology and Biological Faculty, M.V. Lomonosov Moscow State University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mashreghi, Mir Farzin" sort="Mashreghi, Mir Farzin" uniqKey="Mashreghi M" first="Mir-Farzin" last="Mashreghi">Mir-Farzin Mashreghi</name>
<affiliation wicri:level="3"><nlm:affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strowig, Till" sort="Strowig, Till" uniqKey="Strowig T" first="Till" last="Strowig">Till Strowig</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig</wicri:regionArea>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rutz, Sascha" sort="Rutz, Sascha" uniqKey="Rutz S" first="Sascha" last="Rutz">Sascha Rutz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Immunology, Genentech, San Francisco, CA, USA. saschar@gene.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Immunology, Genentech, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kallies, Axel" sort="Kallies, Axel" uniqKey="Kallies A" first="Axel" last="Kallies">Axel Kallies</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. axel.kallies@unimelb.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Scheffold, Alexander" sort="Scheffold, Alexander" uniqKey="Scheffold A" first="Alexander" last="Scheffold">Alexander Scheffold</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Immunology, Christian-Albrechts-Universität zu Kiel & Universitätsklinik Schleswig Holstein, Kiel, Germany. alexander.scheffold@uksh.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Immunology, Christian-Albrechts-Universität zu Kiel & Universitätsklinik Schleswig Holstein, Kiel</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
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<series><title level="j">Nature immunology</title>
<idno type="eISSN">1529-2916</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Colitis (immunology)</term>
<term>Cytokines (metabolism)</term>
<term>Dysbiosis (MeSH)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>Homeostasis (MeSH)</term>
<term>Immunoglobulin A (biosynthesis)</term>
<term>Interleukin-10 (biosynthesis)</term>
<term>Intestines (immunology)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Microbiota (MeSH)</term>
<term>Proto-Oncogene Proteins c-maf (genetics)</term>
<term>Proto-Oncogene Proteins c-maf (metabolism)</term>
<term>Proto-Oncogene Proteins c-maf (physiology)</term>
<term>T-Lymphocytes, Regulatory (enzymology)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>Th17 Cells (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules Th17 (immunologie)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Colite (immunologie)</term>
<term>Cytokines (métabolisme)</term>
<term>Dysbiose (MeSH)</term>
<term>Homéostasie (MeSH)</term>
<term>Immunoglobuline A (biosynthèse)</term>
<term>Interleukine-10 (biosynthèse)</term>
<term>Intestins (immunologie)</term>
<term>Lymphocytes T régulateurs (enzymologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Microbiote (MeSH)</term>
<term>Protéines proto-oncogènes c-maf (génétique)</term>
<term>Protéines proto-oncogènes c-maf (métabolisme)</term>
<term>Protéines proto-oncogènes c-maf (physiologie)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Immunoglobulin A</term>
<term>Interleukin-10</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-maf</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Proto-Oncogene Proteins c-maf</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Immunoglobuline A</term>
<term>Interleukine-10</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Lymphocytes T régulateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>T-Lymphocytes, Regulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines proto-oncogènes c-maf</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules Th17</term>
<term>Colite</term>
<term>Intestins</term>
<term>Lymphocytes T régulateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Colitis</term>
<term>Intestines</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th17 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Protéines proto-oncogènes c-maf</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines proto-oncogènes c-maf</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Proto-Oncogene Proteins c-maf</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Dysbiosis</term>
<term>Gene Expression Regulation</term>
<term>Homeostasis</term>
<term>Mice, Inbred C57BL</term>
<term>Microbiota</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Dysbiose</term>
<term>Homéostasie</term>
<term>Microbiote</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en">Foxp3<sup>+</sup>
regulatory T cells (T<sub>reg</sub>
cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinal T<sub>reg</sub>
cells to constrain microbiota-dependent interleukin (IL)-17-producing helper T cell (T<sub>H</sub>
17 cell) and immunoglobulin A responses critically required expression of the transcription factor c-Maf. The terminal differentiation and function of several intestinal T<sub>reg</sub>
cell populations, including RORγt<sup>+</sup>
T<sub>reg</sub>
cells and follicular regulatory T cells, were c-Maf dependent. c-Maf controlled T<sub>reg</sub>
cell-derived IL-10 production and prevented excessive signaling via the kinases PI(3)K (phosphatidylinositol-3-OH kinase) and Akt and the metabolic checkpoint kinase complex mTORC1 (mammalian target of rapamycin) and expression of inflammatory cytokines in intestinal T<sub>reg</sub>
cells. c-Maf deficiency in T<sub>reg</sub>
cells led to profound dysbiosis of the intestinal microbiota, which when transferred to germ-free mice was sufficient to induce exacerbated intestinal T<sub>H</sub>
17 responses, even in a c-Maf-competent environment. Thus, c-Maf acts to preserve the identity and function of intestinal T<sub>reg</sub>
cells, which is essential for the establishment of host-microbe symbiosis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30778241</PMID>
<DateCompleted><Year>2019</Year>
<Month>04</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20</Volume>
<Issue>4</Issue>
<PubDate><Year>2019</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Nature immunology</Title>
<ISOAbbreviation>Nat Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>c-Maf-dependent T<sub>reg</sub>
cell control of intestinal T<sub>H</sub>
17 cells and IgA establishes host-microbiota homeostasis.</ArticleTitle>
<Pagination><MedlinePgn>471-481</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41590-019-0316-2</ELocationID>
<Abstract><AbstractText>Foxp3<sup>+</sup>
regulatory T cells (T<sub>reg</sub>
cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinal T<sub>reg</sub>
cells to constrain microbiota-dependent interleukin (IL)-17-producing helper T cell (T<sub>H</sub>
17 cell) and immunoglobulin A responses critically required expression of the transcription factor c-Maf. The terminal differentiation and function of several intestinal T<sub>reg</sub>
cell populations, including RORγt<sup>+</sup>
T<sub>reg</sub>
cells and follicular regulatory T cells, were c-Maf dependent. c-Maf controlled T<sub>reg</sub>
cell-derived IL-10 production and prevented excessive signaling via the kinases PI(3)K (phosphatidylinositol-3-OH kinase) and Akt and the metabolic checkpoint kinase complex mTORC1 (mammalian target of rapamycin) and expression of inflammatory cytokines in intestinal T<sub>reg</sub>
cells. c-Maf deficiency in T<sub>reg</sub>
cells led to profound dysbiosis of the intestinal microbiota, which when transferred to germ-free mice was sufficient to induce exacerbated intestinal T<sub>H</sub>
17 responses, even in a c-Maf-competent environment. Thus, c-Maf acts to preserve the identity and function of intestinal T<sub>reg</sub>
cells, which is essential for the establishment of host-microbe symbiosis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Neumann</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Cellular Immunology, Clinic for Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blume</LastName>
<ForeName>Jonas</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roy</LastName>
<ForeName>Urmi</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Teh</LastName>
<ForeName>Peggy P</ForeName>
<Initials>PP</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
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<ForeName>Ajithkumar</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Beller</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liao</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinrich</LastName>
<ForeName>Frederik</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arenzana</LastName>
<ForeName>Teresita L</ForeName>
<Initials>TL</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Immunology, Genentech, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hackney</LastName>
<ForeName>Jason A</ForeName>
<Initials>JA</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5922-563X</Identifier>
<AffiliationInfo><Affiliation>Department of Bioinformatics and Computational Biology, Genentech, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eidenschenk</LastName>
<ForeName>Celine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biochemical and Cellular Pharmacology, Genentech, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gálvez</LastName>
<ForeName>Eric J C</ForeName>
<Initials>EJC</Initials>
<AffiliationInfo><Affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stehle</LastName>
<ForeName>Christina</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5016-0588</Identifier>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinz</LastName>
<ForeName>Gitta A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maschmeyer</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sidwell</LastName>
<ForeName>Tom</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Yifang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amsen</LastName>
<ForeName>Derk</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Sanquin Research, Department of Hematopoiesis and Landsteiner Laboratory, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Romagnani</LastName>
<ForeName>Chiara</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5167-7463</Identifier>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Medical Department I, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Hyun-Dong</ForeName>
<Initials>HD</Initials>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kruglov</LastName>
<ForeName>Andrey</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4597-2087</Identifier>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Belozersky Institute of Physico-Chemical Biology and Biological Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mashreghi</LastName>
<ForeName>Mir-Farzin</ForeName>
<Initials>MF</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-8015-6907</Identifier>
<AffiliationInfo><Affiliation>German Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biology, University of Melbourne, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Strowig</LastName>
<ForeName>Till</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0185-1459</Identifier>
<AffiliationInfo><Affiliation>Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rutz</LastName>
<ForeName>Sascha</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-2431-0938</Identifier>
<AffiliationInfo><Affiliation>Department of Cancer Immunology, Genentech, San Francisco, CA, USA. saschar@gene.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kallies</LastName>
<ForeName>Axel</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-6312-6968</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. axel.kallies@unimelb.edu.au.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. axel.kallies@unimelb.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scheffold</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0626-343X</Identifier>
<AffiliationInfo><Affiliation>Institute of Immunology, Christian-Albrechts-Universität zu Kiel & Universitätsklinik Schleswig Holstein, Kiel, Germany. alexander.scheffold@uksh.de.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>02</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Nat Immunol</MedlineTA>
<NlmUniqueID>100941354</NlmUniqueID>
<ISSNLinking>1529-2908</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C495608">Maf protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051257">Proto-Oncogene Proteins c-maf</NameOfSubstance>
</Chemical>
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</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003092" MajorTopicYN="N">Colitis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064806" MajorTopicYN="N">Dysbiosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016753" MajorTopicYN="N">Interleukin-10</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064307" MajorTopicYN="Y">Microbiota</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051257" MajorTopicYN="N">Proto-Oncogene Proteins c-maf</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058504" MajorTopicYN="N">Th17 Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>10</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>01</Month>
<Day>07</Day>
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<Month>2</Month>
<Day>20</Day>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Pays-Bas</li>
<li>Russie</li>
<li>États-Unis</li>
</country>
<region><li>Berlin</li>
<li>Californie</li>
<li>District fédéral central</li>
<li>Hollande-Septentrionale</li>
<li>Schleswig-Holstein</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Amsterdam</li>
<li>Berlin</li>
<li>Kiel</li>
<li>Melbourne</li>
<li>Moscou</li>
</settlement>
<orgName><li>Université d'Amsterdam</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Berlin"><name sortKey="Neumann, Christian" sort="Neumann, Christian" uniqKey="Neumann C" first="Christian" last="Neumann">Christian Neumann</name>
</region>
<name sortKey="Beller, Alexander" sort="Beller, Alexander" uniqKey="Beller A" first="Alexander" last="Beller">Alexander Beller</name>
<name sortKey="Chang, Hyun Dong" sort="Chang, Hyun Dong" uniqKey="Chang H" first="Hyun-Dong" last="Chang">Hyun-Dong Chang</name>
<name sortKey="Galvez, Eric J C" sort="Galvez, Eric J C" uniqKey="Galvez E" first="Eric J C" last="Gálvez">Eric J C. Gálvez</name>
<name sortKey="Heinrich, Frederik" sort="Heinrich, Frederik" uniqKey="Heinrich F" first="Frederik" last="Heinrich">Frederik Heinrich</name>
<name sortKey="Heinz, Gitta A" sort="Heinz, Gitta A" uniqKey="Heinz G" first="Gitta A" last="Heinz">Gitta A. Heinz</name>
<name sortKey="Kruglov, Andrey" sort="Kruglov, Andrey" uniqKey="Kruglov A" first="Andrey" last="Kruglov">Andrey Kruglov</name>
<name sortKey="Maschmeyer, Patrick" sort="Maschmeyer, Patrick" uniqKey="Maschmeyer P" first="Patrick" last="Maschmeyer">Patrick Maschmeyer</name>
<name sortKey="Mashreghi, Mir Farzin" sort="Mashreghi, Mir Farzin" uniqKey="Mashreghi M" first="Mir-Farzin" last="Mashreghi">Mir-Farzin Mashreghi</name>
<name sortKey="Neumann, Christian" sort="Neumann, Christian" uniqKey="Neumann C" first="Christian" last="Neumann">Christian Neumann</name>
<name sortKey="Romagnani, Chiara" sort="Romagnani, Chiara" uniqKey="Romagnani C" first="Chiara" last="Romagnani">Chiara Romagnani</name>
<name sortKey="Romagnani, Chiara" sort="Romagnani, Chiara" uniqKey="Romagnani C" first="Chiara" last="Romagnani">Chiara Romagnani</name>
<name sortKey="Roy, Urmi" sort="Roy, Urmi" uniqKey="Roy U" first="Urmi" last="Roy">Urmi Roy</name>
<name sortKey="Scheffold, Alexander" sort="Scheffold, Alexander" uniqKey="Scheffold A" first="Alexander" last="Scheffold">Alexander Scheffold</name>
<name sortKey="Stehle, Christina" sort="Stehle, Christina" uniqKey="Stehle C" first="Christina" last="Stehle">Christina Stehle</name>
<name sortKey="Strowig, Till" sort="Strowig, Till" uniqKey="Strowig T" first="Till" last="Strowig">Till Strowig</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Blume, Jonas" sort="Blume, Jonas" uniqKey="Blume J" first="Jonas" last="Blume">Jonas Blume</name>
</region>
<name sortKey="Blume, Jonas" sort="Blume, Jonas" uniqKey="Blume J" first="Jonas" last="Blume">Jonas Blume</name>
<name sortKey="Hu, Yifang" sort="Hu, Yifang" uniqKey="Hu Y" first="Yifang" last="Hu">Yifang Hu</name>
<name sortKey="Hu, Yifang" sort="Hu, Yifang" uniqKey="Hu Y" first="Yifang" last="Hu">Yifang Hu</name>
<name sortKey="Kallies, Axel" sort="Kallies, Axel" uniqKey="Kallies A" first="Axel" last="Kallies">Axel Kallies</name>
<name sortKey="Kallies, Axel" sort="Kallies, Axel" uniqKey="Kallies A" first="Axel" last="Kallies">Axel Kallies</name>
<name sortKey="Liao, Yang" sort="Liao, Yang" uniqKey="Liao Y" first="Yang" last="Liao">Yang Liao</name>
<name sortKey="Liao, Yang" sort="Liao, Yang" uniqKey="Liao Y" first="Yang" last="Liao">Yang Liao</name>
<name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<name sortKey="Sidwell, Tom" sort="Sidwell, Tom" uniqKey="Sidwell T" first="Tom" last="Sidwell">Tom Sidwell</name>
<name sortKey="Sidwell, Tom" sort="Sidwell, Tom" uniqKey="Sidwell T" first="Tom" last="Sidwell">Tom Sidwell</name>
<name sortKey="Teh, Peggy P" sort="Teh, Peggy P" uniqKey="Teh P" first="Peggy P" last="Teh">Peggy P. Teh</name>
<name sortKey="Teh, Peggy P" sort="Teh, Peggy P" uniqKey="Teh P" first="Peggy P" last="Teh">Peggy P. Teh</name>
<name sortKey="Vasanthakumar, Ajithkumar" sort="Vasanthakumar, Ajithkumar" uniqKey="Vasanthakumar A" first="Ajithkumar" last="Vasanthakumar">Ajithkumar Vasanthakumar</name>
<name sortKey="Vasanthakumar, Ajithkumar" sort="Vasanthakumar, Ajithkumar" uniqKey="Vasanthakumar A" first="Ajithkumar" last="Vasanthakumar">Ajithkumar Vasanthakumar</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Arenzana, Teresita L" sort="Arenzana, Teresita L" uniqKey="Arenzana T" first="Teresita L" last="Arenzana">Teresita L. Arenzana</name>
</region>
<name sortKey="Eidenschenk, Celine" sort="Eidenschenk, Celine" uniqKey="Eidenschenk C" first="Celine" last="Eidenschenk">Celine Eidenschenk</name>
<name sortKey="Hackney, Jason A" sort="Hackney, Jason A" uniqKey="Hackney J" first="Jason A" last="Hackney">Jason A. Hackney</name>
<name sortKey="Rutz, Sascha" sort="Rutz, Sascha" uniqKey="Rutz S" first="Sascha" last="Rutz">Sascha Rutz</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Amsen, Derk" sort="Amsen, Derk" uniqKey="Amsen D" first="Derk" last="Amsen">Derk Amsen</name>
</region>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Kruglov, Andrey" sort="Kruglov, Andrey" uniqKey="Kruglov A" first="Andrey" last="Kruglov">Andrey Kruglov</name>
</region>
</country>
</tree>
</affiliations>
</record>
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